Transient Prolongation of Ventricular Action Potential Duration after Metabolic Inhibition.
نویسندگان
چکیده
منابع مشابه
Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization.
AIMS Sustained ventricular fibrillation (VF) is maintained by multiple stable rotors. Destabilization of sustained VF could be beneficial by affecting VF complexity (defined by the number of rotors). However, underlying mechanisms affecting VF stability are poorly understood. Therefore, the aim of this study was to correlate changes in arrhythmia complexity with changes in specific electrophysi...
متن کاملIonic Mechanisms of Desflurane on Prolongation of Action Potential Duration in Rat Ventricular Myocytes
PURPOSE Despite the fact that desflurane prolongs the QTC interval in humans, little is known about the mechanisms that underlie these actions. We investigated the effects of desflurane on action potential (AP) duration and underlying electrophysiological mechanisms in rat ventricular myocytes. MATERIALS AND METHODS Rat ventricular myocytes were enzymatically isolated and studied at room temp...
متن کاملHuman ventricular action potential duration restitution.
. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391–6. . Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 1999;100:1660–6. . Breithardt G, Cain ME, El-Sheri...
متن کاملInstability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic.
BACKGROUND Prolongation of action potential duration (APD) is considered a major antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic (torsade de pointes). METHODS AND RESULTS The cardiac electrophysiological effects of 702 chemicals (class 2I or HERG channel block) were studied in 1071 rabbit Langendorff-perfused hearts. Temporal instability of APD, tri...
متن کاملSignificant prolongation of atrial monophasic action potential duration: short-term reverse electrophysiological changes after internal cardioversion of atrial fibrillation.
OBJECTIVE Since short action potentials and short refractory periods facilitate the induction of atrial reentry, this maladaptation has been proposed as the pathophysiological basis of the frequent immediate recurrences of atrial fibrillation (IRAF) after internal cardioversion. However, short-term reverse electrophysiological changes of the atria after cardioversion have not been studied in hu...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1995
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.36.775